Vitamin E does not prevent Western diet-induced NASH progression and increases metabolic flux dysregulation in mice
Fatty liver involves ectopic lipid accumulation and dysregulated hepatic oxidative metabolism, which can progress to a state of elevated inflammation and fibrosis referred to as nonalcoholic steatohepatitis (NASH).The factors that control progression from simple steatosis to NASH are not fully known.Here, we tested the hypothesis that dietary vitam