VITAMIN E DOES NOT PREVENT WESTERN DIET-INDUCED NASH PROGRESSION AND INCREASES METABOLIC FLUX DYSREGULATION IN MICE

Vitamin E does not prevent Western diet-induced NASH progression and increases metabolic flux dysregulation in mice

Fatty liver involves ectopic lipid accumulation and dysregulated hepatic oxidative metabolism, which can progress to a state of elevated inflammation and fibrosis referred to as nonalcoholic steatohepatitis (NASH).The factors that control progression from simple steatosis to NASH are not fully known.Here, we tested the hypothesis that dietary vitam

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Effect of Intravenous Thrombolytic Dose of Alteplase on Long-Term Prognosis in Patients with Acute Ischemic Stroke

Abstract Introduction This study aimed to click here investigate the long-term prognostic effects of different alteplase doses on patients with acute ischemic stroke (AIS).Methods In this cohort study, we enrolled 501 patients with AIS treated with intravenous thrombolysis with alteplase, with the primary endpoint event of recurrence of ischemic st

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325 Predictors of Substance Use Initiation by Late Childhood: Findings from the Adolescent Brain Cognitive Development (ABCD) Study

OBJECTIVES/GOALS: Adolescence represents a critical period for substance use initiation.Various factors may contribute to trying a sip or single puff of a substance, that could lead to more frequent use.However, less is known about how predictors from multiple domains converge to impact risk for general substance use initiation.METHODS/STUDY POPULA

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